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FLASH GENE
Symbol ANAPC2 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 2
HGNC id 19989
Location 9q34.3      Physical location : 140.069.235 - 140.083.057
Synonym name
  • anaphase-promoting complex/cyclosome
  • cyclosome subunit 2
    • Synonym symbol(s) APC2, KIAA1406, RP11-350O14.5
    DNA
    TYPE functioning gene
    STRUCTURE 13.82 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2733 - 822 - Yu (1998)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousbraindiencephalonhypothalamus  
     braindiencephalonamygdala  
     nerve   highly
    Reproductivefemale systemovary   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C terminal cullin homology domain
    • HOMOLOGY
    Homologene
    FAMILY
  • cullin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • involved in regulation of axonal growth and synaptic functions in postmitotic neurons
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
    • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin dependent catabolism
    a component
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inversin (interaction dependent on a conseved D-box motif)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS