protein
| UBL1 |
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SMT3H1 |
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nucleophosmin (NPM1) is an SENP3-binding partner (SENP3-mediated desumoylation might control NPM1 physiological functions at both the nucleolus and other subcellular compartments) |
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specific interaction partner of CDCA8 and catalyzes the removal of SUMO2/3 from CDCA8 |
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interacts with STUB1 and Hsp90 in differential modes under non-stress and oxidative stress conditions |
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interacts with TP53 and MDM2, desumoylates both proteins and bound to the acidic domain of MDM2, which also mediates the TP53 interaction, and competed with TP53 for binding |
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PELP1 and the PELP1-associated factor LAS1L are SENP3-sensitive targets of SUMO |
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LAS1L interacts with PELP1, and WDR18, the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 and SENP3, to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit |
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key target for SENP3-mediated deSUMOylation is the GTPase DNM1L, which plays a major role in regulating mitochondrial fission |
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nutrient-sensing MTOR kinase pathway controls the nucleolar targeting of SENP3 by regulating its interaction with NPM1 |
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regulates the global protein turnover and the SP1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation |
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SENP3 could thus enhance STAT3 phosphorylation by de-conjugating the SUMO2/3 modification of STAT3 |
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SENP3-mediated deSUMOylation of DNM1L facilitates interaction with MFF to promote cell death |
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MAP2K7, which selectively phosphorylates MAPK8, is a SENP3 substrate and SENP3-mediated deSUMOylation of MAP2K7 may favor its binding to MAPK8 |