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FLASH GENE
Symbol POTED contributors: mct/npt - updated : 14-03-2014
HGNC name POTE ankyrin domain family, member D
HGNC id 23822
Location 21q11.2      Physical location : 14.982.497 - 15.013.906
Synonym name
  • expressed in prostate, ovary, testis, and placenta
  • ankyrin repeat domain 21
  • ANKRD26-like family B, member 3
  • pote protein
  • cancer/testis antigen family 104, member 1
  • Synonym symbol(s) POTE, ANKRD21, POTE-21, POTE21, A26B3, CT104.1
    DNA
    TYPE functioning gene
    STRUCTURE 32.41 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1826 66.4 584 - 2006 1639721
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     female systemplacenta   
     male systemtestis  predominantly Homo sapiens
     male systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    Reproductivespermatocyte
    cell lineage
    cell lines prostatic cancer cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal cysteine rich domain (CRD), palmitoylated on paired cysteine residues in each CRD motif (palmitoylation is responsible of the strong association with plasma membrane)
  • seven ankyrin repeats
  • spectrin-like helices
  • an alpha-helical C terminus
  • HOMOLOGY
    intraspecies paralog to POTEB, POTEG, POTEH, POTEA, POTEF, POTEE, POTEK
    Homologene
    FAMILY
  • POTE gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an important role in reproductive processes
  • might be involved in transmitting signals from the cell surface (Bera 2004)
  • may have a role in apoptosis in the human testis, and involved in apoptosis of testicular germ cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may have a role in apoptosis in the human testis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS