basic FUNCTION
| regulating TNF alpha-mediated apoptosis in a p53-dependent manner |
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CDIP1 expression correlates with sensitivity of cancer cells with TNF, and CDIP1 seems to be a regulator of the TP53-mediated death versus survival response of cells to TNF |
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upon ER stress, CDIP1 is induced and enhances an association with BCAP31 at the ER membrane |
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CDIP1/BCAP31-mediated regulation of mitochondrial apoptosis pathway represents a mechanism for establishing an ER-mitochondrial crosstalk for ER-stress-mediated apoptosis signaling 1) |
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CDIP1 (cell death involved p53 target 1), displays identical membrane topology, as LITAF, suggesting that this mode of membrane integration is conserved in LITAF family proteins |