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FLASH GENE
Symbol CDIP1 contributors: mct - updated : 10-07-2018
HGNC name cell death inducing p53 target 1
HGNC id 13234
Location 16p13.3      Physical location : -
Synonym name
  • LITAF-like protein
  • chromosome 16 open reading frame 5
  • transmembrane protein I1
  • Synonym symbol(s) I1, CDIP, C16orf5, LITAFL
    DNA
    TYPE functioning gene
    STRUCTURE 28.14 kb     6 Exon(s)
    text structure at least six exons
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2505 - 129 - 2016 27582497
    6 - 2625 - 169 - 2016 27582497
    6 - 2742 - 208 - 2016 27582497
    6 - 2774 - 208 - 2016 27582497
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain   highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-glycosylation site, and a high content of proline residues (40p100 over 104 residues) at the N-terminus of the protein
  • three N-myristoyllation sites
  • two phosphorylation sites
  • C-terminus of the protein is also cysteine rich with 14 cysteine residues present
  • HOMOLOGY
    Homologene
    FAMILY LITAF family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulating TNF alpha-mediated apoptosis in a p53-dependent manner
  • CDIP1 expression correlates with sensitivity of cancer cells with TNF, and CDIP1 seems to be a regulator of the TP53-mediated death versus survival response of cells to TNF
  • upon ER stress, CDIP1 is induced and enhances an association with BCAP31 at the ER membrane
  • CDIP1/BCAP31-mediated regulation of mitochondrial apoptosis pathway represents a mechanism for establishing an ER-mitochondrial crosstalk for ER-stress-mediated apoptosis signaling 1)
  • CDIP1 (cell death involved p53 target 1), displays identical membrane topology, as LITAF, suggesting that this mode of membrane integration is conserved in LITAF family proteins
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • proapoptotic TP53 target, CDIP1, acts as a key signal transducer of ER-stress-mediated apoptosis
  • BCAP31 is an interacting partner of CDIP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS