basic FUNCTION
| playing an important role in cell proliferation and/or anti-apoptosis, and may be serving as a molecular marker for AML |
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functions as an important regulator in the non-canonical NFKB pathway through the stabilization and activation of MAP3K14 via K63-linked polyubiquitination |
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may play a role in hematopoietic repopulating cells |
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stabilizes and activates NFKB-inducing kinase (MAP3K14) in ubiquitination-dependent manner |
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functions as an E3 ligase directly to MAP3K14, and is an important regulator of the noncanonical NFKB pathway |
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critical regulator in TNFSF14-induced activation of non-canonical NFKB pathway |
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may be involved in the regulation of non-canonical NFKB pathway but not canonical NFKB pathway |
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involved in the regulation of DNA-binding activity of p52 and RELB |
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key factor in activation of noncanonical NFKB1 signaling pathway as well as to be involved in HIF1A signaling in cancer cells |
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involved in the prostate diseases, benign prostate hyperplasia, or prostate cancer |
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role for ZFP91 in the production of biologically active IL1B ( |