Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZFP91 contributors: mct - updated : 10-09-2018
HGNC name zinc finger protein 91 homolog (mouse)
HGNC id 14983
Location 11q12.1      Physical location : 58.346.586 - 58.388.513
Synonym symbol(s) PZF, FKSG11, DMS-8, ZFP-91, ZNF757
EC.number 2.3.2.27
DNA
TYPE functioning gene
STRUCTURE 41.93 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 5735 63.4 570 - 2003 12738986
monocistronic fragment
11 - 5732 - 569 testis specific 2003 12738986
fusion protein of ZFP91 and CNTF
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 thymus   predominantly
Reproductivefemale systemuteruscervix  
 male systemtestis   
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five zinc-finger domains
  • a leucine zipper
  • and several nuclear localization signals
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY zinc finger protein family (C2H2) type
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing an important role in cell proliferation and/or anti-apoptosis, and may be serving as a molecular marker for AML
  • functions as an important regulator in the non-canonical NFKB pathway through the stabilization and activation of MAP3K14 via K63-linked polyubiquitination
  • may play a role in hematopoietic repopulating cells
  • stabilizes and activates NFKB-inducing kinase (MAP3K14) in ubiquitination-dependent manner
  • functions as an E3 ligase directly to MAP3K14, and is an important regulator of the noncanonical NFKB pathway
  • critical regulator in TNFSF14-induced activation of non-canonical NFKB pathway
  • may be involved in the regulation of non-canonical NFKB pathway but not canonical NFKB pathway
  • involved in the regulation of DNA-binding activity of p52 and RELB
  • key factor in activation of noncanonical NFKB1 signaling pathway as well as to be involved in HIF1A signaling in cancer cells
  • involved in the prostate diseases, benign prostate hyperplasia, or prostate cancer
  • role for ZFP91 in the production of biologically active IL1B (
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+ binding
    protein
  • interacts with and promotes the Lys(63)-linked ubiquitination of MAP3K14 and subsequent processing of p100 to p52
  • ZFP91 is a key regulator in TNFSF14-induced activation of non-canonical NFKB1 pathway in LTBR signaling
  • ZFP91 may serve as a driver gene to activate HIF1A transcription in the development of cancer
  • ZFP91 promotes non-canonical CASP8 inflammasome complex assembly
  • enhances the activation of ERK, MAPK14 and JNK in macrophages
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myelogenous leukemia
    tumoral     --over  
    in prostate cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may present new opportunities for the potential treatment of cancers and inflammation-driven diseases with persistent NFKB response
    immunologyinflammatory 
    may be a promising therapeutic target for intervention in inflammatory, infectious, and autoimmune related diseases
    ANIMAL & CELL MODELS