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FLASH GENE
Symbol ZDHHC6 contributors: mct - updated : 09-01-2013
HGNC name zinc finger, DHHC domain containing 6
HGNC id 19160
Location 10q25.2      Physical location : 114.190.059 - 114.206.672
Synonym name
  • probable palmitoyltransferase ZDHHC6
  • transmembrane protein H4
  • zinc finger protein 376
    • Synonym symbol(s) ZNF376, FLJ21952
    EC.number 2.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 16.62 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2187 - 413 - 1999 10395086
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved Cys 4 zinc-finger like metal binding domain
  • a complex Cys-His region
  • DHHC/NEW1 domain, potentially involved in protein-protein or protein-DNA interaction
  • ER targeting signal in DHHC6 is conform to a KKXX motif, C-terminal pentapeptide sequences required for ER localization of DHHC4 and DHHC6
    • HOMOLOGY
    interspecies homolog to Drosophila DNZ1
    Homologene
    FAMILY
  • DHHC palmitoyltransferase family
  • DHHC/NEW1 subfamily
    • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • restricted localization of ZDHHC4 and ZDHHC6 to ER membranes
    • basic FUNCTION
  • putative transcription factor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • ZDHHC6, which modifies key proteins of the endoplasmic reticulum, is controlled by an upstream palmitoyltransferase, ZDHHC16, revealing the first palmitoylation cascade
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS