protein
| STK15 |
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interacting with TRAF2 |
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modifyed by ISG15 (suppresses its ubiquitin-conjugating activity) |
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ZNRF2, interact with UBE2N through its RING finger domain |
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TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBE2N and UBE2V1 to catalyse Lys 63-linked polyubiquitination, which activates the MAP3K7 kinase complex |
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OTUB1 binding to and inhibiting UBE2N, the cognate E2 enzyme for RNF168 and pharmacological targeting of the OTUB1-UBE2N interaction might enhance the DNA damage response |
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function of TRIM5 is dependent on its association with the E2 ubiquitin-conjugating enzyme complex UBE2N-UBE2V1 and subsequent activation of the MAP3K7 complex and downstream genes involved in innate immune responses |
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RNF8 regulates K48- and K63-linked poly-ubiquitylation via differential RING-dependent interactions with its E2s UBE2L6 and UBE2N, respectively |
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OTUB1 binding also occludes the RING E3 binding site on UBE2N, thus providing a further component of inhibition |
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UBE2N activity and its interaction with STUB1 precede endocytosis of GHR |
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UBE2N-CHUK signaling axis regulates the molecular program that maintains Treg cell function and prevents Treg cells from acquiring inflammatory phenotypes |
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RNF8 interacts with UBE2N in a manner that is similar to that of the RING-type E3 ubiquitin ligase TRAF6 and the U-box-type E3 ubiquitin ligase, STUB1 |
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OTUB1 inhibits Lys-63-linked ubiquitination by binding to a ubiquitin-conjugating enzyme UBE2N |
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C1orf86 preferentially binds the ubiquitin product of RNF8-UBE2N, and this ubiquitin-binding activity and RNF8-UBE2N are both required for recruitment of C1orf86 to interstrand crosslinks |
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implicated in a bipartite role in priming and amplifying lys63-linked ubiquitin chains on histone molecules through coupling with the E3 RNF8 and RNF168 |
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OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex with E2 ubiquitin (Ub)-conjugating enzymes including UBE2N and UBE2D1 |
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ATM-dependent phosphorylation of BCL10 promotes its interaction with and presentation of UBE2N to RNF8, and RNF8-mediated ubiquitination of BCL10 enhances binding of BCL10 and UBE2N to RNF168 |
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UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy |
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ZNRF1 is an essential E3 ligase implicated in diverse cellular pathways, and that binds UBE2N |