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FLASH GENE
Symbol GFUS contributors: mct - updated : 02-06-2020
HGNC name GDP-L-fucose synthase
HGNC id 12390
Location 8q24.3      Physical location : -
Synonym name
  • tissue specific transplantation antigen P35B
  • Synonym symbol(s) FX, P35B, TSTA3, SDR4E1
    EC.number 1.1.1.271
    DNA
    TYPE functioning gene
    STRUCTURE 5.43 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1391 - 327 - 2013 23774504
    11 - 1345 - 321 - 2013 23774504
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • key catalytic residues that could be useful for the design of drugs for the treatment of inflammation, auto-immune diseases, and possibly certain types of cancer
  • secondary structure four loops in the structure of human protein corresponding to two alpha-helices
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • important substrate involved in the biosynthesis of many glycoproteins
  • amplification of GMDS and TSTA3, likely contributes to the elevated core fucose observed in hepatocellular carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    likely contributes to the elevated core fucose observed in hepatocellular carcinoma
    tumoral     --other  
    altered expression of fucosylation pathway gene(GFUS), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a novel biomarker for prognosis of patients with esophageal squamous cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS