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FLASH GENE
Symbol STARD7 contributors: mct - updated : 05-01-2011
HGNC name StAR-related lipid transfer (START) domain containing 7
HGNC id 18063
Location 2q11.2      Physical location : 96.850.604 - 96.874.573
Synonym name
  • START domain containing 7
  • gestational trophoblastic tumor protein 1
  • stAR-related lipid transfer protein 7, mitochondrial
  • Synonym symbol(s) GTT1
    DNA
    TYPE functioning gene
    STRUCTURE 23.98 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure StarD7 promoter is activated by TCF4 transcription factor and by its beta-catenin coactivator
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 3394 - 370 - 2004 15013637
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta    Homo sapiens
     male systemtestis    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text
  • trophoblastic tissues, placenta
  • human trophoblast cells
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a StAR-related lipid transfer (START) domain defined as a motif of around 200 AAs implicated in lipid/sterol binding
  • HOMOLOGY
    Homologene
    FAMILY StAR-related lipid transfer family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • its surface activity is strong enough to thermodynamically drive and retain STARDD7 at the lipid membrane interface where it may undergo lipid-dependent reorganization
  • mediates transplacental lipid transport and/or is involved in syncytialization
  • with CDK10 could potentially be involved in cell differentiation and growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by beta-catenin and TCF4 which activate the STARD7 interacting with its promoter region through Wnt/beta-catenin signalling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • may serve as potential targets for therapy of prognostication of seminomas
  • ANIMAL & CELL MODELS