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FLASH GENE
Symbol SLC4A1AP contributors: mct/npt - updated : 17-04-2010
HGNC name solute carrier family 4 (anion exchanger), member 1, adaptor protein
HGNC id 13813
Location 2p23.2      Physical location : 27.886.337 - 27.917.846
Synonym name
  • kanadaptin
  • lung cancer oncogene 3
  • kidney anion exchanger adapter protein
    • Synonym symbol(s) FLJ10624, kanadaptin, HLC3, FLJ41004, MGC120646, MGC120648
    DNA
    TYPE functioning gene
    STRUCTURE 31.51 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2982 90 796 - Hubner (2003)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidneytubulecollecting duct highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 4
    • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text mitochondrial localization (Hubner 2003)
    basic FUNCTION
  • may have a signalling role in the nucleus (Hubner 2002)
  • highly mobile nucleocytoplasmic shuttling and multilocalizing protein, having nuclear export activity (Hubner 2003)
  • adaptor protein or chaperone that may not be involved in the biosynthesis and targeting of SLC4A1 (Kittanakom 2004)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding activity to the cytoplasmic domain of the kidney Na(+)-independent Cl(-)/HCO(-)(3) anion exchanger 1 (SLC4A1) (Hubner 2002)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS