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FLASH GENE
Symbol SEZ6 contributors: mct/npt/pgu - updated : 10/12/2008
HGNC name seizure related 6 homolog (mouse)
HGNC id 15955
Location 17q11.2      Physical location : 27.281.946 - 27.333.081
Synonym name seizure related 6 homolog
DNA
TYPE functioning gene
STRUCTURE 51.16 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4234 107 993 - 2007 17086543
16 - 4250 - 994 - 2007 17086543
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrainforebrain   
Reproductivemale systemtestis   
Visualeye    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in the developing forebrain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • SEZ6 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • transmembrane protein on the plasma membrane of neuronal cells
  • basic FUNCTION
  • having a forebrain-specific role during development
  • in the adult hippocampus, is a CA1-specific regional marker
  • required for normal dendritic arborization of cortical neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEZ6 bound to the proline-rich/kringle domain of motopsin, and interaction of motopsin and SEZ6 modulates the neuronal cell morphology
  • cell & other
    REGULATION
    activated by convulsant drug
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to febrile seizures
    Variant & Polymorphism
    Candidate gene candidate gene for epilepsy
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    sez-6 null mice display specific exploratory, motor, and cognitive deficits