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FLASH GENE
Symbol STARD10 contributors: mct - updated : 08-03-2017
HGNC name START domain containing 10
HGNC id 10666
Location 11q13.4      Physical location : 72.465.774 - 72.504.750
Synonym name
  • similar to phosphatidylcholine transfer protein 2
  • serologically defined colon cancer antigen 28
  • antigen NY-CO-28
  • Synonym symbol(s) PCTP2, CGI-52, SDCCAG28, NY-CO-28
    DNA
    TYPE functioning gene
    STRUCTURE 38.98 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1988 - 291 - 2005 15911624
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Mus musculus
     liver   highly Homo sapiens
    Reproductivemale systemtestis    Mus musculus
    Urinarykidney     Mus musculus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Mus musculus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    cell lineage
    cell lines various cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a steroidogenic acute regulatory protein (StAR)-related lipid transfer (“StART”) domain
  • HOMOLOGY
    Homologene
    FAMILY steroidogenic acute regulatory protein (StAR)-related lipid transfer protein family
    CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be required in the acute regulation of steroidogenesis
  • may function in the secretion of phospholipids into the bile
  • is involved in regulating bile acid metabolism through the modulation of PPARA-mediated mechanism
  • phospholipid transfer protein possessing a steroidogenic acute regulatory protein (StAR)-related lipid transfer (“StART”) domain that facilitates the transport of phosphatidylcholine and phosphatidylethanolamine between intracellular membranes
  • is required for normal insulin secretion, though its deletion enhances proinsulin processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STAR/STARD3/STARD5, STARD5, PCTP/STARD10, STARD10 and COL4A3BP, respectively
  • LPCAT1 interacts with STARD10, and AAs 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction
  • cell & other
    REGULATION
    Phosphorylated by phosphorylated on serine 284, and C-terminal STARD10 phosphorylation on serine 284 regulates its association with cellular membranes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduction in STARD10 expression in the beta cells associated to type 2 diabetes
    tumoral     --over  
    in breast cancer
    Susceptibility to type 2 diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • fecal excretion of bile acids was significantly increased in Stard10(-/-) mice