SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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basic FUNCTION
| paired basic amino-acid residue cleaving enzyme 4 |
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involved in the dentinogenesis (via the activation of BMP) |
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proprotein convertase responsible for activation of aggrecanases in osteoarthritic and cytokine-stimulated cartilage |
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its activation may modulate the bioactivity of proteins secreted in the optic nerve head and retina |
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can play an important role in myogenic differentiation |
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through its association with the IGF-II pathway |
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proprotein convertase (PC) responsible for cleaving and activating proteins that contribute to enhance tumor progression |
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protease that cleaves the left–right axis determining protein NODAL |
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FURIN, PCSK5, and PCSK6 process two triglyceride lipase family members, endothelial lipase and lipoprotein lipase, which are important for HDL remodeling |