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FLASH GENE
Symbol RASSF3 contributors: mct/npt - updated : 15-03-2010
HGNC name Ras association (RalGDS/AF-6) domain family 3
HGNC id 14271
Location 12q14.2      Physical location : 65.004.292 - 65.089.190
Synonym symbol(s) MGC119194, MGC119195, MGC119197, RASSF5
DNA
TYPE functioning gene
STRUCTURE 84.90 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1337 - 238 - Tommasi (2002)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved Ras association (RalGDS/AF-6) (RA) domain at the C-terminus
  • HOMOLOGY
    intraspecies homolog to RASSF1
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • may be involved in neuropeptide signaling pathway
  • may function as tumour suppressors by regulating the cell cycle and apoptosis (van der Weyden 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    may influence mammary tumor incidence in MMTV/neu transgenic mice (Jacquemart 2009)