protein
| interacting with ECT2 and regulating the activation and function of CDC42 in mitosis |
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linking CEP55 through a cellular mechanism which, in turn, controls the midbody structure and membrane fusion at the terminal stage of cytokinesis |
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interacting with HIF1A (HIF-1alpha function is negatively affected by its interaction with RACGAP1) |
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interacts with KIF23 to form the centralspindlin complex and associates with the RhoGEF ECT2 (PMID : |
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expression of ECT2, RACGAP1, and KIF23 is tightly regulated during cell cycle progression |
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CUX1 and E2F1 regulate coordinated expression of the mitotic complex genes ECT2, RACGAP1, and KIF23 in S phase |
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at anaphase, binding to RACGAP1 at the spindle midzone repositions ECT2 to induce local actomyosin ring formation |
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is a crucial regulator of RAC1 in adherent cells and that inhibition of RAC1-dependent effector pathways in anaphase is needed for cytokinesis |
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is a GAP for RAC1 and CDC42 but not RHOA |
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negatively controls the activity of RAC1 and CDC42, which are key molecular switches acting on the microtubule and actin cytoskeleton and controlling various cell processes such as proliferation, adhesion and motility |
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RACGAP1 promoted the activations of RHOA, PTK2, PXN and triggered focal adhesion formation and cytoskeletal rearrangement |
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ECT2 binds to RACGAP1 via its N-terminal BRCT domain (BRCA1 C-terminal), which docks at specific phosphorylated residues |