basic FUNCTION
| having transcription factor activity and functioning as a tumor suppressor in association with HIF1A |
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may be an oxidative stress responding regulator in lung cells |
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controls the stability of RCHY1, an E3 ubiquitin ligase for TP53 |
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transcription factor of the surfactant protein C (SP-C) promoter (Yang 2009) |
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having a pathogenic role in pulmonary emphysema, a critical aspect of severe chronic obstructive pulmonary disease (Yang 2009) |
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regulate the pro-apoptotic factor, BNIP3, demonstrating that PLAGL2 may also function as a tumor suppressor (Wezensky 2010) |
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plays a role in the regulation of NCF2, the gene encoding the NADPH oxidase cytosolic protein NCF2, but not sufficient to activate an NCF2 promoter-reporter plasmid, suggesting the requirement for other factors (Wezensky 2010) |
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with MED15, and SPI1 cooperate to enhance NCF2 promoter-reporter activity (Wezensky 2010) |