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FLASH GENE
Symbol PLAGL2 contributors: mct/npt - updated : 28-05-2010
HGNC name pleiomorphic adenoma gene-like 2
HGNC id 9047
Location 20q11.21      Physical location : 30.780.306 - 30.795.546
Synonym name
  • Xenopus finger protein homolog
  • C2H2-type zinc finger protein
  • pleiomorphic adenoma-like protein 2
  • Synonym symbol(s) KIAA0198, FLJ23283
    DNA
    TYPE functioning gene
    STRUCTURE 15.24 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5656 - 496 - Guo (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
     mouthtongue  highly
    Endocrineparathyroid   highly
    Hearing/Equilibriumear   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney, liver, lung, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nuclear localization signal (NLS)located in the N-terminal domain with six C2H2 zinc fingers
  • an activation domain in the C-terminus (Wezensky 2010)
  • HOMOLOGY
    interspecies homolog to murine Plagl2
    intraspecies homolog to PLAG1
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having transcription factor activity and functioning as a tumor suppressor in association with HIF1A
  • may be an oxidative stress responding regulator in lung cells
  • controls the stability of RCHY1, an E3 ubiquitin ligase for TP53
  • transcription factor of the surfactant protein C (SP-C) promoter (Yang 2009)
  • having a pathogenic role in pulmonary emphysema, a critical aspect of severe chronic obstructive pulmonary disease (Yang 2009)
  • regulate the pro-apoptotic factor, BNIP3, demonstrating that PLAGL2 may also function as a tumor suppressor (Wezensky 2010)
  • plays a role in the regulation of NCF2, the gene encoding the NADPH oxidase cytosolic protein NCF2, but not sufficient to activate an NCF2 promoter-reporter plasmid, suggesting the requirement for other factors (Wezensky 2010)
  • with MED15, and SPI1 cooperate to enhance NCF2 promoter-reporter activity (Wezensky 2010)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • with HIF1A
  • interacting with UBE2I (functioned as a co-factor of PLAGL2 on the surfactant protein-C promoter and the co-activation was independent of its SUMOylation enzymatic activity)
  • direct binding of PLAGL2 to the NCF2 promoter sequence (Wezensky 2010)
  • interaction between PLAGL2 and MED15 (Wezensky 2010)
  • cell & other
    REGULATION
    Other post-translationally modified by small ubiquitin-like modifier (SUMO), known as SUMOylation, and by acetylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia, with chromosome 16 inversion
    constitutional     --over  
    in alveolar epithelial cells correlated with the development of emphysema in the lung of chronic obstructive pulmonary disease patients (Yang 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS