motifs/domains
| four cysteine residues, a potential glycosylation site |
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a nuclear localization signal (NLS) |
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six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop |
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possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 8) |
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a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic |
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a Ca2+-permeable channel pore in the C terminus, peptide derived from the C-terminal end(CTP1), corresponding to AAs 198217 inducing Ca2+ release from the ER |
basic FUNCTION
| acting as a suppressor of apoptosis |
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increases Ca(2+) leak rates from the ER through a mechanism that is dependent on pH and on the C-terminal cytosolic region of the TMBIM6 protein |
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play a role in apoptosis |
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increased actin polymerization and cell adhesion through Ca2+ regulation and actin interaction |
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conserved endoplasmic reticulum protein that suppresses the apoptosis induced by BAX, a pro-apoptotic member of the BCL2 family |
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endoplasmic reticulum (ER)-resident transmembrane protein that can interact with multiple partners to alter intracellular Ca(2+) flux control and lipid dynamics |
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common cell death suppressor that has provided a potential portal to this cell death core |
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has Ca2+ channel properties likely relevant for its function in ER stress and apoptosis |
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like TMBIM4, TMBIM6 also protects cells against intrinsic pro-apoptotic stimuli and lowers resting Ca2+ concentrations in the ER, which reduces Ca2+ release from intracellular stores upon stimulation, thus dampening the apoptotic response |
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promotes autophagy in an inositol triphosphate receptors (IP& |
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8323;Rs)-dependent manner |
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is a novel autophagy regulator that bridges CaČ& |
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8314; signaling between ER and mitochondria, reducing cellular oxygen consumption and contributing to cellular resilience in the face of metabolic stress |
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conserved six-transmembrane domain endoplasmic reticulum (ER)-localized protein that protects against ER stress-induced apoptotic cell death |
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associated with calcium (Ca(2+)) levels, reactive oxygen species (ROS) production, cytosolic acidification, and autophagy as well as endoplasmic reticulum stress signaling pathways |
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plays a regulatory role in mitochondrial Ca(2+) levels |
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plays a key role in the synthesis, folding, and sorting of proteins, and disturbances of this delicate system can cause cell death |
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conserved multifunctional protein that mediates Ca(2+) efflux from the ER and protects against ER stress |
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evolutionarily conserved pH-dependent CaČ& |
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8314; leak channel in the endoplasmic reticulum and the founding member of a family of six highly hydrophobic mammalian proteins named transmembrane BAX inhibitor motif containing (TMBIM) |
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reduce the CaČ& |
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8314; content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting CaČ& |
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8314; concentration |