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FLASH GENE
Symbol NSFL1C contributors: mct - updated : 14-03-2015
HGNC name NSFL1 (p97) cofactor (p47)
HGNC id 15912
Location 20p13      Physical location : 1.422.812 - 1.448.417
Synonym name
  • SHP1 homolog
  • UBX domain-containing protein 2C
  • Synonym symbol(s) P47, dJ776F14.1, UBX1, UBXD10, UBXN2C
    DNA
    TYPE functioning gene
    STRUCTURE 25.53 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3568 40 368 - 1998 9824302
    8 - 3475 - 339 - 1998 9824302
    10 - 3574 - 372 - 1998 9824302
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineplacenta    
    Lymphoid/Immunethymus    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one UBX domain
    HOMOLOGY
    interspecies homolog to murine LOC381642
    homolog to rattus p47
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • VCIP1 and NSFL1C are shown to function in Golgi
  • and ER assembly
  • localization and phosphorylation of NSFL1C are important for Golgi disassembly-assembly during the cell cycle
  • essential factor for Golgi membrane fusion
  • is critical for negatively regulating stimulation-induced IKK activation in a manner that is mechanistically distinct from the previously characterized negative regulators, such as TNFAIP3 and CYLD
  • UBXN2B/NSFL1C adaptors of VCP regulate mitosis by limiting the centrosomal recruitment of AURKA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VCP-binding protein, functions in Golgi membrane fusion together with VCP and VCPIP1, another VCP-binding protein
  • associates with the IKBKG subunit of the IKB kinase (IKK) complex upon TNF or IL1 stimulation, and inhibits IKK activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS