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FLASH GENE
Symbol NEK5 contributors: mct - updated : 25-11-2014
HGNC name NIMA (never in mitosis gene a)-related kinase 5
HGNC id 7748
Location 13q14.3      Physical location : 52.638.901 - 52.703.214
Synonym name NimA-related protein kinase 5
Synonym symbol(s) MGC75495
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 64.32 kb     22 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 2949 81.3 708 - 2013 23727203
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • protein kinase superfamily
  • NEK Ser/Thr protein kinase family
  • NIMA subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • having a kinase activity
  • promotes myogenic differentiation through up-regulation of caspase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role of NEK5, identified as a novel substrate for CASP3, in skeletal muscle differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of NEK5 mRNA expression was accompanied by cell differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS