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FLASH GENE
Symbol MYH7B contributors: mct - updated : 24-03-2020
HGNC name myosin, heavy polypeptide 7B, cardiac muscle, beta
HGNC id 15906
Corresponding disease
LVNC13 left ventricular noncompaction 13
Location 20q11.22      Physical location : 33.543.703 - 33.590.239
Synonym name
  • myosin heavy chain-like
  • slow A MYH14
  • U937-associated antigen
  • antigen MLAA-21
  • Synonym symbol(s) KIAA1512, dJ756N5.1, MYH14, MHC14, MGC96928, MGC96940
    DNA
    TYPE functioning gene
    STRUCTURE 16.57 kb     43 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    45 - 6551 226 1983 - 2016 27666969
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
     heart   lowly Homo sapiensFetal
    Nervousbrain     Homo sapiens
    Reproductivefemale systemovary  lowly Homo sapiens
    Respiratorylung   lowly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac   Homo sapiens
    Muscularstriatumskeletal   Homo sapiens
    Muscularstriatumskeletal lowly Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • is localized to dendritic spines
  • MYH7B and MYH15, are expressed in muscle spindles
  • basic FUNCTION
  • having a motor activity
  • conforms to a sarcomeric motor consensus, which suggests it has a unique function relative to the nonmuscle isoforms expressed in neurons
  • maintains synaptic strength in hippocampal neurons through an actin-dependent mechanism
  • MYH7B and MYH10 have distinct and overlapping effects on spine morphology
  • is necessary for steady-state synaptic transmission in hippocampal neurons
  • MYH7B and MYH15 play a prominent role in the heart and skeletal muscles of certain species like chicken and snakes, whereas in mammals, the only muscles that these myosin motors function in are highly specialized muscles
  • may have a role that uniquely fits a contractile requirement of the specialized muscles
  • expression of MYH7b protein in the mammalian heart has been inhibited during the evolution of mammals most likely to prevent the development of a severe cardiomyopathy that is sexually dimorphic
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • maintains excitatory synaptic function by regulating F-actin filaments associated with AMPA receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LVNC13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquiredheart failure
    activation of myosin by omecamtiv mecarbil may provide a new therapeutic approach for systolic heart failure
    ANIMAL & CELL MODELS