protein
| ligand for fusin/LESTR (leukocyte-expressed CXCR4) |
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interacting with SDC4 |
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interacting with IGF2 (has the ability to strongly stimulate osteoclastogenesis by regulating PPBP expression in stromal cells and CXCL12 expression in osteoblastic cells) |
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with PPBP may promote the formation of giant osteoclasts |
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ligand for CXCR7 |
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interacting with SOCS3 (SOCS3-regulated CXCL12-induced FAK phosphorylation through the ubiquitin-proteasome pathway) |
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interacting with RUNX3 (CXCL12 autocrine/paracrine signaling down-regulates the expression of the transcription factor RUNX3 and contributes to maintain the long-term CD4 and CD14 expression in monocytes/macrophages) |
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positive correlation between CXCL12 signaling and SNAI2 activity, thus corroborating the role of these two proteins in bone cellular context |
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both ACKR3 and CXCR4 are important for endothelial progenitor cells (EPCs) in response to CXCL12 |
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GNAI2 and ZAP70 mediate RASGRP1 membrane localization and activation of CXCL12-induced T cell functions |
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ACKR3 plays an important role in human cord blood derived endothelial progenitor cells (EPCs) in response to CXCL12 |
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HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 |
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regulatory pathways targeting ACKR3 C-terminal serine/threonine sites may control the CXCL12 scavenger activity of ACKR3 |
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CXCL12 protects neural progenitor cells (hNPCs) from apoptotic challenges through CXCR7- and CXCR4-mediated endocytotic signaling |
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ACKR3 can relay CXCL12 signaling in the cell |
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ACKR3 plays an important role on cell repair processing induced by CXCL12, and ACKR3 silencing attenuates cell adaptive response to acute CXCL12 stimulation after hypoxia |
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CXCL12-dependent migration of human malignant B cells requires both PI3K signaling and PLEKHA2 |
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CXCL14 represents, along with CXCR7, molecules that co-evolved with the CXCL12-CXCR4 axis to modulate important physiological processes in development, stem cell maintenance, and immune responses |
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ACKR3 binds the chemokines CXCL12 and CXCL11 |
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interfering with the CXCL12-scavenging activity of CXCR7 causes loss of CXCR4 function as a consequence of excessive CXCL12-mediated CXCR4 activation and degradation |
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RGS3 bridges ephrin-B reverse signaling and CXCL12 induced G protein signaling |
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addition of CXCL12 leads to the dissociation of EIF2S2 from CXCR4 suggesting that stimulation of the receptor may trigger the local protein synthesis required for efficient cell movement |
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NR4A1 binds directly to the CXCL12 promoter, resulting in inhibition of CXCL12 expression |
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GNG4 is an inhibitor of CXCL12/CXCR4-dependent signaling |
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PTK2B/STAP2 interaction is a novel mechanism to regulate CXCL12-dependent T-cell chemotaxis |