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FLASH GENE
Symbol MMP27 contributors: - updated : 04-05-2004
HGNC name matrix metalloproteinase 27
HGNC id 14250
Location 11q24      Physical location : 102.562.414 - 102.576.468
Synonym symbol(s) MMP-27
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a prodomain
  • a catalytic domain with Zn+ binding motif
  • an hemoplexin-like domain
  • conjugated HemoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY matrix metalloproteinase (MMP) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION involved in proteolysis and peptidolysis by metallo-endopeptidase activity
    CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein binding TIMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    activated by proteinases
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS