basic FUNCTION
| transforming growth factor beta, receptor, menbrane bound serine/threonine kinase, receptor type |
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could be involved in capturing and retaining tgf-beta for presentation to the signaling receptors |
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heparan sulfate proteoglycan with a short cytoplasmic tail that functions as a TGF-beta superfamily co-receptor, contributing to TGF-beta signaling |
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playing a specific role for clathrin-independent endocytosis in regulating both Smad-dependent and Smad-independent TGF-beta signaling |
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presence of TGFBR3 is required for normal cord formation, normal fetal Leydig cell development, and the establishment of fetal testis endocrine function, thus implicating TGFB superfamily members as regulators of early fetal testis structure and function |
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coreceptor for members of the transforming growth factor beta (TGF-beta) superfamily |
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mediates TGF-beta superfamily ligand dependent as well as ligand independent signaling to both Smad and non-Smad signaling pathways |
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role as a suppressor of cancer progression and/or as a metastasis suppressor |
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TGFBR3 increases basal TGFbeta signalling |
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may act as a protective factor in apoptotic process of cardiac fibroblasts by negative regulation of TGFB signaling and represent a potential therapeutic target for heart remodeling after hypoxia injury |
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plays a central role in regulating responsiveness not only to members of the TGFB family but select mediators of epicardial cell function such FGF2 |
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plays a crucial role in thymocyte differentiation |
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inhibins and TGFBR may function as a molecular pair regulating T cell development |
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TGFBR3 is a novel regulator of BAIAP2/WAS via CDC42 to regulate filopodial formation and cell adhesion |