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FLASH GENE

Symbol

KRTAP4-12

contributors: npt/ - updated : 28-07-2003

HGNC name	keratin associated protein 4-12
HGNC id	16776

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.2      Physical location : 39.279.346 - 39.280.419
Synonym name	ultrahigh sulfur keratin-associated protein 4.12
Synonym symbol(s)	KAP4.12, KRTAP4.12

DNA

TYPE	functioning gene
STRUCTURE	1.07 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KRTAP4-12 1 - 1077 21.3 201 - Rogers (2001)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin appendages hair

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	highly conserved amino-terminal end region, MV(S/N)SCC
	a central region of highly repetitive, di-cysteine-containing pentamers, separated by occasional pentameric, non-repetitive segments

HOMOLOGY

Homologene

FAMILY

KRTAP type 4 family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament

basic FUNCTION

involved in formation of the matrix associated with keratin intermediate microfilaments

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	hair fibers formation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS