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FLASH GENE
Symbol IRS4 contributors: mct - updated : 01-09-2020
HGNC name insulin receptor substrate 4
HGNC id 6128
Corresponding disease
CHNG9 hypothyroidism, congenital, nongoitrous, 9
Location Xq22.3      Physical location : 107.975.726 - 107.979.607
Synonym name 160 kDa phosphotyrosine protein
Synonym symbol(s) IRS-4, PY160
DNA
TYPE functioning gene
STRUCTURE 16.64 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 3881 133.6 1257 - -
2 - 6563 - 1256 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain
  • a phosphotyrosine binding (PTB) domain
  • two regions (amino acids 335-400 and 1094-1257) of IRS4 were related to bind to the C- terminal region of USP18
  • twelve potential tyrosine phosphorylation sites in the C terminal region
  • HOMOLOGY
    interspecies ortholog to murine Irs4
    homolog to Drosophila chico
    Homologene
    FAMILY
  • IRS family
  • CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text cytoplasmic side of plasma membrane
    basic FUNCTION
  • mediating the biological response to insulin stimulation by binding and activating various enzymes or adaptor molecules
  • association of IRS4 with SSH1 contributes likely to localized activation of cofilin in membrane protrusions
  • IRS4 hyperactivates the phosphatidylinositol phosphate kinase (PI3K)-pathway independent of upstream signals and is irresponsive to feedback regulation causing cancer
  • is particularly critical in the myoblast stage to serve as a molecular switch between BMP/SMAD and AKT1 signalling and to thereby control cell commitment
  • IRS4 is a novel USP18-binding protein that can be used to boost the host innate immunity to control HCV, and potentially other viruses that are sensitive to IFNA2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • the SH2 domain of PIK3s and GRB2 proteins
  • INSR, IRAS
  • IRS4 interacts with the LEPR
  • IRS4 is a novel SSH1-binding protein
  • IRS4 likely promotes cofilin dephosphorylation through sequential activation of PI3K and SSH1 but not through AKT1
  • IRS4 functioned as a novel USP18-binding protein
  • cell & other
    REGULATION
    activated by osmotic stress
    ASSOCIATED DISORDERS
    corresponding disease(s) CHNG9
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    is a potential therapeutic target for cancers with high expression of this protein
    ANIMAL & CELL MODELS