basic FUNCTION
| mediating the biological response to insulin stimulation by binding and activating various enzymes or adaptor molecules |
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association of IRS4 with SSH1 contributes likely to localized activation of cofilin in membrane protrusions |
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IRS4 hyperactivates the phosphatidylinositol phosphate kinase (PI3K)-pathway independent of upstream signals and is irresponsive to feedback regulation causing cancer |
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is particularly critical in the myoblast stage to serve as a molecular switch between BMP/SMAD and AKT1 signalling and to thereby control cell commitment |
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IRS4 is a novel USP18-binding protein that can be used to boost the host innate immunity to control HCV, and potentially other viruses that are sensitive to IFNA2 |