basic FUNCTION
| involved in lipopolysaccharide signal transduction, negative regulator |
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TOLL-like receptor (TLR) signaling, preventing dissociation of IRAK1 and IRAK4 from MYD88 and the formation of IRAK/TRAF6 complexes |
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involved in the pathogenesis of early-onset persistent asthma |
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play a pivotal role in the process of 'endotoxin tolerance' in human monocytes |
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initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression |
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IRAK3 is an important target for CASP6 (neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IRAK3) |