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FLASH GENE
Symbol IL18RAP contributors: mct - updated : 06-06-2008
HGNC name interleukin 18 receptor accessory protein
HGNC id 5989
Location 2q12.1      Physical location : 103.035.253 - 103.069.022
Synonym name
  • accessory protein-like
  • CD218b antigen
  • interleukin-1 receptor 7
  • IL-1R accessory protein-like
    • Synonym symbol(s) ACPL, CD218b, CDw218b, IL18RB, MGC120589, MGC120590, IL-18RAcP, IL1R7
    DNA
    TYPE functioning gene
    STRUCTURE 33.77 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2668 68.3 599 - 2008 18439550
    EXPRESSION
    Rna function testis
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
     thymus    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immunemacrophage
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 14-amino acid signal peptide
  • a 342-amino acid extracellular (Ig superfamily-like) segment
  • three Ig like domains
  • three glycosylation potential sites
  • single transmembrane region
  • a 222-amino acid cytoplasmic domain
    • mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Il18rap
    Homologene
    FAMILY
  • interleukin-1 receptor (IL-1R) family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required for induction of NFkappaB activity and for activation of c-Jun N-terminal kinase
  • pleiotropic cytokine involved in the regulation of both innate and adaptive immunity and playing a key role in the autoimmune, inflammatory and infectious diseases
  • essential for IL-18 signal transduction and ligand binding affinity to IL-18Ralpha receptor chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text Th1 immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimerizing with IL18R1
  • component of IL18 receptor
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by IFN-alpha,IL-12
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Crohn's disease and ulcerative colitis
    Variant & Polymorphism SNP increasing the risk of Crohn's disease and ulcerative colitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS