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FLASH GENE
Symbol IL17D contributors: - updated : 30-07-2003
HGNC name interleukin 17D
HGNC id 5984
Location 13q12.11      Physical location : 21.277.481 - 21.297.236
Genatlas name interleukin 17D resting CD4+ T-cells, resting CD19+ B-cells
Synonym name interleukin 27
Synonym symbol(s) IL27, IL-22, IL-27, IL-17D
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Lymphoid/Immunespleen    
Nervousbrain    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectiveadipose   
Epithelialsecretoryglandularendocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immuneactivated B lymphocyte
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an homodimerization motif with conserved cysteines
  • an unique extended C-terminal domain
  • mono polymer homomer , monomer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Il17d
    intraspecies homolog to IL17
    Homologene
    FAMILY IL17 family
    CATEGORY secretory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulating cytokine production in endothelial cells
  • inhibiting hemopoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS