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FLASH GENE
Symbol EPHA7 contributors: mct - updated : 10-07-2019
HGNC name EPH receptor A7
HGNC id 3390
Location 6q16.1      Physical location : 93.949.741 - 94.129.300
Synonym name Ephrin type-A receptor 7 precursor
Synonym symbol(s) HEK11, EHK3, EPA7, EHK-3, EK11
EC.number 2.7.1.112/ 2.7.10.1
DNA
TYPE functioning gene
STRUCTURE 179.56 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • five TCF/LEF-binding sites were identified within the 5prime-promoter region of the EPHA7 gene
  • PBX1 was found to bind directly to the EPHA7 promoter in the developing cortex
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 6644 - 998 - 2007 15902206
    3 - 1935 - 279 - 2007 15902206
    17 - 6606 - 993 - 2007 15902206
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
     vessel   moderately Homo sapiens
    Digestiveintestinesmall intestine  predominantly
    Nervousbrain   moderately
    Urinarykidney   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SAM domain
  • two fibronectin type 3 domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Epha7
    ortholog to murine Epha7
    Homologene
    FAMILY
  • TYR family of protein kinases
  • ephrin receptor subfamily
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to membrane
  • type I membrane protein
    • basic FUNCTION
  • may be mediating cellular adhesion or repulsion during embryonic development
  • acting as a receptor for members of the ephrin-A family
  • playing a key role in controlling the size of cerebral cortex by regulating cortical progenitor cell apoptosis
  • EFNA2 and EPHA7 as negative regulators of progenitor cell proliferation
  • later in neuronal maturation, EPHA7 influences protrusions from dendritic shafts and the assembling of synaptic components
  • potential role of EPHA7 in the regulation of cell adhesion during pronephros development, whereas soluble EPHA7 works as an antagonist
  • new role of EPHA7 in PCOS (polycystic ovary syndrome), suggesting that EPHA7 is an effective target for the development of innovative medicines to induce ovulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • EFNA1
  • EFNA2
  • EFNA3
  • EFNA4
  • EFNA5
  • PRKCABP
  • GRIP1
  • interacting with HOXA13 (HOXA13 directly regulates EPHA6 and EPHA7 in the developing GT (genital tubercle) and identifies the GT vascular endothelia as a novel site for HOXA13-dependent expression of EPHA6 and EPHA7)
  • DLX5 and MSX2 play potentially a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the EPHA5 and EPHA7 pathway
  • EPHA7 interacts with CASP8 to induce apoptotic cell signaling
  • EPHA7 regulates GPHN clustering and the maintenance of inhibitory synaptic connectivity via MTOR signalling
  • EPHA7 is a novel direct BMI1 target in neural cells and lymphocytes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal cancer, via aberrant 5'CpG island methylation
    tumoral       loss of function
    in follicular lymphoma (FL)
    tumoral     --over  
    expressed at a substantial level in most human lung cancers and the secreted form of EPHA7 mRNA was found in a fraction of primary lung cancer tissues
    tumoral     --over  
    correlates with adverse outcome in primary and recurrent glioblastoma multiforme
    tumoral     --over  
    in prostate cancer cells resulted in decreased tumor volume and increased tumor apoptosis in primary tumors
    tumoral        
    in several different human tumor types including lymphomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    tumor suppressor with immediate therapeutic potential in follicular lymphoma
    cancerreproductiveprostate
    receptor phosphorylation of EPHA7, at least in part, suppress PCa tumor malignancy through targeting PI3K/Akt signaling pathways
    reproductionfertility 
    effective target for the development of innovative medicines to induce ovulation
    ANIMAL & CELL MODELS