basic FUNCTION
| specifying a putative nuclear transcription factor, functioning in regulating the response to growth factors |
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acting as as an essential regulator of ARE-dependent mRNA decay |
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might also be an important player during myogenic differentiation and regeneration, and an important regulator of myogenesis |
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may be an important regulator of VEGF expression |
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modulator of vascular endothelium growth factor (VEGF) mRNA stability, and important role of ZFP36L1 in wound healing |
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role for ZFP36L1 and ZFP36L2 during thymocyte development and in the prevention of malignant transformation |
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negatively regulates erythroid differentiation by directly binding the 3prime untranslated region of STAT5B encoding mRNA |
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effective in repressing a broad spectrum of target mRNAs bearing structurally distinct AREs in tumor cells |
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enhances vascular endothelial growth factor (VEGF) mRNA decay through its interaction with AU-rich elements within VEGF 3prime-untranslated region |
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involved in AU-rich-dependent regulation of mRNA stability/degradation |
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ZFP36L1-mediated mechanism is used by endothelial cells under hypoxia for controlling DLL4 mRNA levels |
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new function in mammalian cell mRNA 3prime-end maturation |
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acts as a positive regulator to participate in monocyte/macrophage differentiation |
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in developing B lymphocytes, the RNA-binding proteins (RBPs) ZFP36L1 and ZFP36L2 are critical for maintaining quiescence before precursor B cell receptor (pre-BCR) expression and for reestablishing quiescence after pre-BCR-induced expansion |
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ZFP36, ZFP36L1, and ZFP36L2, regulates the production of growth factors and cytokines via destabilization of the respective mRNAs |
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both ZFP36 and ZFP36L1 influence keratinocyte cell cycle, differentiation, and apoptosis in a distinct manner |
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in addition to controlling the timing of proliferation at thymic beta-selection, posttranscriptional control by ZFP36L1/L2 limits DNA damage responses, which are known to promote thymocyte differentiation |
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indispensable role for ZFP36L1 as the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival |
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ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion |
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ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor to obesity and hepatosteatosis |
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ZFP36L1 and ZFP36L2 inhibit cell proliferation in a CCND-dependent and TP53-independent manner |
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RNA-binding protein ZFP36L1 functions as a tumor suppressor by regulating the mRNA stability of a number of mRNAs involved in hypoxia and cell-cycle signaling |
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ZFP36L1 and ZFP36L2 act redundantly in myogenesis |
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ZFP36, ZFP36L1, and ZFP36L2, play key roles in the post-transcriptional regulation of gene expression |