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FLASH GENE
Symbol AK8 contributors: mct - updated : 25-05-2021
HGNC name adenylate kinase 8
HGNC id 16715
Location 9q34.13      Physical location : -
Synonym name
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31
  • DEAD/DEXH helicase DDX31
  • G2 helicase
  • helicain
  • Synonym symbol(s) FLJ13633, FLJ14578, FLJ23349, DDX31, C9orf98
    EC.number 3.6.1.-/ 2.7.4.3/ 2.7.4.6
    DNA
    TYPE functioning gene
    STRUCTURE 153.47 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1579 - 479 - 2011 21080915
    13 - 1586 - 275 - 2011 21080915
    13 - 1559 - 450 - 2011 21080915
    14 - 1651 - 275 - 2011 21080915
    11 - 1444 - 434 - 2011 21080915
    13 - 1621 - 275 - 2011 21080915
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DEAD/H box (Asp - Glu - Ala - Asp/His)
  • C terminal RNA helicase domain
  • two complete and active AK domains within its polypeptide chain, a feature that has previously been shown for AK5
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX31/DBP7 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • cytosolic localization
  • AK8, is present in a third flagellar compartment, the axoneme of sperm tail
  • basic FUNCTION
  • both AK7 and AK8 showed highest affinity for AMP with ATP as the phosphate donor, and are more efficient in AMP phosphorylation as compared with the major cytosolic isoform AK1 (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS