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FLASH GENE
Symbol DDX28 contributors: - updated : 05-02-2005
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
HGNC id 17330
Location 16q22.2      Physical location : 68.055.178 - 68.057.770
Synonym name
  • mitochondrial DEAD-box polypeptide 28
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28
  • Synonym symbol(s) MDDX28,FLJ11282
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TSNAXIP1 16q22.2 translin-associated factor X interacting protein 1 FLJ13111 16q22.1 hypothetical protein FLJ13111 THAP11 16q22.1 THAP domain containing 11 NUTF2 16q22.2 nuclear transport factor 2 RCD-8 16q22.1 autoantigen UNQ2446 16q22.1 MRCC2446 PSKH1 16q22.1 protein serine kinase H1 CTRL 16q22.1 chymotrypsin-like PSMB10 16q22.1 proteasome (prosome, macropain) subunit, beta type, 10 LCAT 16q22.1 lecithin-cholesterol acyltransferase SLC12A4 16q22.1 solute carrier family 12 (potassium/chloride transporters), member 4 DPEP3 16q22.1 dipeptidase 3 DPEP2 16q22.1 dipeptidase 2 LOC339065 16q22.1 similar to putative membrane-bound dipeptidase-2 DDX28 16q22.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 FLJ20399 16q22.1 hypothetical protein FLJ20399 NFATC3 16q22.1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal DEAD box (Asp-Glu-Ala-Asp/His) with three basic domains and its RNA binding ability were essential for nucleolar localization as well as transcription-inhibition-dependent localization to nuclear subcompartments
  • a SPRY domain,a second DEAD box and a C terminal helicase domain
  • HOMOLOGY
    Homologene
    FAMILY DEAD-like helicase superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION involved in nucleo-cytoplasmic shuttling dependent on the availability of nascent RNA
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS