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FLASH GENE

Symbol

COTL1

contributors: mct - updated : 28-08-2010

HGNC name	coactosin-like 1 (Dictyostelium)
HGNC id	18304

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q24.1      Physical location : 84.599.205 - 84.651.669
Synonym name	coactosin-like protein
Synonym symbol(s)	CLP, MGC19733, FLJ43657

DNA

TYPE	functioning gene
STRUCTURE	52.47 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021149 4 - 1850 NP_066972 15.8 142 - 2001 11583571

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           pancreas exocrine         Endocrine parathyroid       highly Lymphoid/Immune lymph node       predominantly   tonsils       highly Reproductive female system uterus cervix   highly Skin/Tegument skin         Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

actin depolymerization factor/cofilin-like domain

HOMOLOGY

interspecies

ortholog to murine Cotl1

intraspecies

homolog to Dictyostelium protein stimulating autonomous replication

Homologene

FAMILY	actin-binding proteins ADF family
	coactosin subfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microfilament

basic FUNCTION	regulating the actin cytoskeleton
	in stimulated cells, functioning in a complex together with 5-lipoxygenase (5LO) and membranes, increasing the capacity of 5LO for leukotriene biosynthesis
	playing a role as a chaperoning scaffold factor, influencing both the stability and the activity of ALOX5
	binds to and chaperones ALOX5 in the cytosol of neutrophils

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

leukotriene

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to F-actin in a calcium-independent manner
	and 5 lipoxygenase exclusively from each other
	binds ALOX5 and promotes leukotrienes formation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to autoimmune disorders

Variant & Polymorphism other	c.-1124G>T and c. 484G>A polymorphisms of the COTL1 gene might be associated with the genetic susceptibility of autoimmune disorders

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune   COTL1/ALOX5 as therapy to reduce leukotriene formation in the cell

ANIMAL & CELL MODELS