Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CNOT6L contributors: mct - updated : 25-10-2015
HGNC name CCR4-NOT transcription complex, subunit 6-like
HGNC id 18042
Location 4q13.3      Physical location : 78.634.541 - 78.740.544
Synonym name carbon catabolite repressor protein 4 homolog B
Synonym symbol(s) FLJ23561, FLJ25459, DKFZp434K098, CCR4B
EC.number 3.1.-.-
DNA
TYPE functioning gene
STRUCTURE 106.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 8794 63 555 - 2011 21233283
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal leucine-rich repeat (LRR) domain influenced its subcellular localization but was not required for its deadenylase activity
  • active site of CNOT6L should recognize the RNA substrate through its negatively charged surface
  • HOMOLOGY
    intraspecies homolog to CNOT6
    Homologene
    FAMILY
  • CCR4/nocturin family
  • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • localized mainly in the cytoplasm and displays deadenylase activity
  • basic FUNCTION
  • negative control of cell proliferation associated with cell-cell contact through interaction with BTG1
  • regulates cell growth in a manner dependent on its deadenylase activity
  • may be involved in various cellular events that include cell proliferation
  • play a role in cell survival, in contrast to the CNOT7 and CNOT8 deadenylase subunits of CCR4-NOT complex
  • key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a TP53-dependent pathway
  • CNOT7/8 catalytic subunits are essential for deadenylation, which is necessary to maintain cell viability, whereas CNOT6/6L are not
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CNOT7, CNOT8 cooperate with CNOT6, CNOT6L in mRNA deadenylation, suggesting that the enzyme activities of CNOT7, CNOT8 and CNOT6, CNOT6L are regulated via allosteric interactions within the nuclease module
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS