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FLASH GENE
Symbol CNNM3 contributors: mct - updated : 28-12-2018
HGNC name cyclin and CBS domain divalent metal cation transport mediator 3
HGNC id 104
Location 2q11.2      Physical location : 97.481.990 - 97.501.120
Synonym name
  • ancient conserved domain protein 3
  • metal transporter CNNM3
  • cyclin-M3
  • Synonym symbol(s) ACDP3, DKFZp434I1016, FLJ20018
    DNA
    TYPE functioning gene
    STRUCTURE 21.22 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 4916 76 707 - -
    7 - 4772 70.5 659 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidneytubuleconvoluted tubuleproximal tubule  Other species
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two conserved CBS forming a stable globular domain
  • HOMOLOGY
    interspecies homolog to murine Cnnm3
    Homologene
    FAMILY
  • ACDP family
  • CATEGORY protooncogene , signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • Mg(2+) transporter that is itself pro-oncogenic
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTP4A2 regulates intracellular magnesium levels by forming a functional heterodimer with the magnesium transporter CNNM3
  • PTP4A2 modulates intracellular Mg(2+) levels and sustains cancer phenotypes by binding to the Mg(2+) transporter CNNM3
  • overexpression of ARL15 promotes complex N-glycosylation of CNNM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS