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FLASH GENE
Symbol CMTM8 contributors: mct - updated : 27-01-2014
HGNC name CKLF-like MARVEL transmembrane domain containing 8
HGNC id 19179
Location 3p22.3      Physical location : 32.280.170 - 32.411.811
Synonym name chemokine-like factor super family 8
Synonym symbol(s) CKLFSF8, CKLFSF8-V2
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 131.65 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text encodes two isoform (PMID: 22337876)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1185 - 173 - 2007 17681841
  • CMTM8 and CMTM8-v2 display different expression profiles and distinct subcellular localization patterns, while operating via different mechanisms to induce apoptosis
  • - - - - - - 2007 17681841
  • arises from a deletion of exon 2 that prevents the expression of a full-length MARVEL domain, and cytosolic YXXPhi motifs
  • maintains the ability to induce apoptosis via caspase-dependent and -independent pathways to inhibit cell growth and colony formation
  • did not affect EGFR internalization
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • a MARVEL domain and/or the cytosolic YXXPhi motifs, necessary for CMTM8 to accelerate ligand-induced EGFR internalization
  • HOMOLOGY
    interspecies ortholog to murine Cklfsf8
    intraspecies homolog to TM4SF11
    Homologene
    FAMILY chemokine-like factor gene superfamily
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • novel regulator of EGF-induced signaling and the association of EGFR with four transmembrane proteins is critical for EGFR desensitization
  • accelerates the ligand-induced clearance of epidermal growth factor receptor (EGFR) from the cell surface
  • may inhibit EMT-like processes by interfering with MET/ERK signaling in some tumor cell types
  • functions as a negative regulator of HGF/MET signaling to ERK
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with the epidermal growth factor receptor (EGFR)
  • negative regulator of EGF-induced signaling
  • CMTM8 regulation of EGFR internalization may control cell survival, but its regulation of MET is likely to contribute to the control of cell motility and invasion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    useful target for treatment of cancers with aberrant activation of HGF/MET signaling
    cancer  
    therapeutic gene for EGFR-targeted anticancer gene therapy
    ANIMAL & CELL MODELS