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FLASH GENE
Symbol ABLIM2 contributors: - updated : 26-09-2006
HGNC name actin binding LIM protein family, member 2
HGNC id 19195
Location 4p16-p15      Physical location : 7.967.037 - 8.160.559
Synonym name actin binding LIM protein 2
Synonym symbol(s) KIAA1808, FLJ39684
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 193.00 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure high density of brain and CNS transcription factor binding sites in the promoter region
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two potential isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2589 - 611 - Klimov
20 exons
- - 2472 - 572 - Klimov
18 exons
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart   moderately
Endocrinepancreas    
Nervousbrain   highly
Respiratorylung    
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N terminal cysteine-rich LIM/double zinc finger motifs
  • a C terminal end homolog to actin-bundling domain of erythrocyte cytoskeleton (dematin like domain /villin headpiece domain (VHP)
  • HOMOLOGY
    intraspecies homolog to ABLIM1
    Homologene
    FAMILY LIM protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • involved in cytoskeleton organization and biogenesis
  • playing a necessary role for the normal functioning of neurons
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc, Zn2+
    protein binding to actin and bundling actin filaments
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS