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FLASH GENE
Symbol MS4A6E contributors: - updated : 01-09-2007
HGNC name membrane-spanning 4-domains, subfamily A, member 6E
HGNC id 14285
Location 11q12.1      Physical location : 60.102.354 - 60.108.440
Synonym symbol(s) MGC126832
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 6.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two transmembrane (TM)domains comprising a short intracellular domain
  • four transmembrane segments (4TM)
  • a long cytoplasmic tail, involved in intracellular signaling
  • HOMOLOGY
    interspecies homolog to murine Ms4a2
    intraspecies homolog to MS4A6A
    Homologene
    FAMILY membrane-spanning 4A gene family
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the regulation of B cell activation and proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS