basic FUNCTION
| may be involved in the pathogenesis of this disease through the regulation of adipocyte function |
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regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway |
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WNT3 and WNT5B are critical factors secreted from Transforming growth factor-induced mesenchymal cancer cells for instigating the epithelial cancer cell invasion along with the induction of secondary EMT phenotype |
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role of GPC4 and WNT5B in chondrocyte stacking underlying craniofacial cartilage morphogenesis |
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may play an important role in the tumorigenesis of Colorectal cancer |
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WNT5B induces tube formation by regulating the expression of SNAIl and SNAI2 proteins through activation of canonical and non-canonical WNT signalling pathways |
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WNT5B-associated exosomes promote cancer cell migration and proliferation in a paracrine manner |
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WNT5B signals locally as an early step in basal constriction and acts together with more widespread PTK2 activation |
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exhibits negative effects on bone and might promote the development of osteoporosis |
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WNT5B did not affect the early osteogenic differentiation genes but suppressed the middle and late osteogenic differentiation genes, resulting in inhibition of differentiation and mineralization |