Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ZRANB1

contributors: mct/npt - updated : 15-12-2021

HGNC name	zinc finger, RAN-binding domain containing 1
HGNC id	18224

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q26.13      Physical location : 126.630.691 - 126.676.004
Synonym name	TRAF -binding protein domain
Synonym symbol(s)	TRABID, DKFZp762P2216
EC.number	3.1.2.-/ 3.4.19.12

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	45.31 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017580 9 - 4942 NP_060050 - 708 - 2021 33853758

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive intestine large intestine colon   moderately Endocrine thyroid       moderately Nervous nerve       predominantly Reproductive female system ovary     moderately   female system uterus     moderately Respiratory lung       moderately   respiratory tract trachea     highly Urinary kidney       moderately Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal ankyrin-repeat Ub-binding domain is required for Lys29 and Lys33 linkage specificity
	an ankyrin-repeat ubiquitin-binding domain determines ZRANB1 specificity for atypical ubiquitin chains
	three RANBP2-type zinc fingers (three tandem NZF motifs)
	one OTU domain

HOMOLOGY

interspecies

homolog to murine Zranb1 (99 pc)

intraspecies

homolog to A20

Homologene

FAMILY	peptidase C64 family
	OTU domain deubiquitinase family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	modulating TNF alpha signaling
	may have a function in stem cell self-renewal or differentiation (Tran 2008)
	specifically hydrolyzes both Lys29- and Lys33-linked diubiquitin
	is an innate immunological regulator of inflammatory T cell responses
	is a previously unrecognized inhibitor of hepatocellular carcinoma progression and metastasis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	interacting with TRAF6
	can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription (Tran 2008)
	ZRANB1 is the EZH2 deubiquitinase, and binds, deubiquitinates, and stabilizes EZH2
	E3 ubiquitin ligase HECTD1 is a substrate of ZRANB1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   correlated with poorer survival in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene	is a new candidate prognostic biomarker for HCC treatment
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast therapeutic potential for targeting ZRANB1 in breast cancer

ANIMAL & CELL MODELS