basic FUNCTION
| potent negative regulator of insulin signaling and insulin sensitivity in vivo |
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involved in the control of vascular smooth muscle cells proliferation and the pathogenesis of vascular proliferative disorders |
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playing an important role in the control of insulin sensitivity |
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dephosphorylates phosphatidylinositol 3,4,5-trisphosphate generated by the activated phosphatidylinositol 3'-kinase |
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down-regulates insulin signaling and is present at higher levels in diabetes and obesity |
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functioning in the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation |
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involved in receptor endocytosis regulation |
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could be polyubiquitinated but not degraded by the 26 S proteasome |
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able to recognize other ubiquitinated proteins by a UIM domain and its monoubiquitination is a process that is actively controlled by the ability of its SH2 domain to mask the monoubiquitination site |
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may have functions such as scaffold properties in the c-Jun N-terminal kinase cascade, negative regulation of EGFR internalization and degradation, EphA2 endocytosis, and angiotensin II signaling |
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downregulates insulin signalling in podocytes |
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regulates endocytic clathrin-coated pit dynamics |
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INPPK5 and INPPL1, inhibit actin cytoskeletal reorganization by opposing PI3K/Akt signaling |
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major negative regulator of the phosphatidylinositol-3-kinase pathway in lymphocytes |
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its function is different at the plasma membrane where it recognizes PtdIns(3,4,5)P3, and in the nucleus where it may interact with PtdIns(4,5)P2, particularly in speckles |
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two previously unrecognized functions of INPPL1 in suppressing ligand-induced activation of EPHA2 and in promoting receptor coordinated chemotactic cell migration |
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key and specific role in the endochondral ossification process, through either its role in postranslational modifications (phosphorylation or ubiquitination) or its interaction with specific protein network |
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role of INPPL1 in development in normal cells and at least in cell proliferation in some cancer derived cells |
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associates with receptors that are associated in lymphedema, implicating its direct involvement in the lymphatic vasculature |
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its expression level is a key determinant of hepatic lipogenesis and lipoprotein secretion |
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catalyses the dephosphorylation of the phospholipid phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3) to form PI(3,4)P2 |
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phosphatase that acts at the 5-position of phosphatidylinositol 3,4,5-trisphosphate |
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INPPL1 is a negative regulator of microvilli formation, thereby controlling solute reabsorption by the proximal tubule |
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endothelial INPPL1 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced endothelial dysfunction |
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general role for INPPL1 in the control of cell migration in breast cancer cells and a second messenger role for PI(3,4)P2 in the migration mechanism |
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important role of INPPL1 in chondrocytes during endochondral ossification and its different differentiation steps |
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INPPL1 protein play a determinant role in H2O2-induced apoptosis |
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non-redundant role for the hitherto overlooked INPPL1 in the regulation of neutrophils, and specifically, neutrophil chemotaxis/trafficking |