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FLASH GENE
Symbol NUF2 contributors: mct/npt - updated : 01/10/2008
HGNC name NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
HGNC id 14621
Location 1q23.3      Physical location : 163.291.722 - 163.325.553
Synonym name
  • kinetochore portein Nuf2
  • cell division cycle associated 1
  • Synonym symbol(s) CDCA1, NUF2R
    DNA
    TYPE functioning gene
    STRUCTURE 33.00 kb     15 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 1843 54.2 464 - PA.Wigge
    encoding the same protein than variant 1
    14 splicing 1989 54.2 464 - PA.Wigge
    encoding the same protein than variant 2
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     salivary gland   highly
    Hearing/Equilibriumear   moderately
    Lymphoid/Immunethymus   moderately
    Nervousbrain    
    Reproductivemale systemprostate   
     male systemtestis  highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Cdca1 (79.2 pc)
    homolog to murine Nuf2 (73.2 pc)
    Homologene
    FAMILY
  • NUF2 family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localized to kinetochores from late prophase to anaphase
  • localized specifically to the outer plate of the kinetochore
  • basic FUNCTION
  • acting at the centromere to establish a connection with the spindle for proper chromosome segregation
  • required for the spindle checkpoint
  • kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis (Wei 2006)
  • required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore
  • having a necessary role for correct binding of spindle checkpoint proteins to kinetochore (act independent of each other in kinetochore assembly, but their combined activities are required for checkpoint signaling)
  • kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis (Wei 2006)
  • directly connects kinetochores to spindle microtubules (Wilson-Kubalek 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a conserved protein complex associated with the centromere
  • component of the essential kinetochore- associated NDC80 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CENPH (for kinetochore assembly)
  • cell & other
    REGULATION
    Other can be phosphorylated by AURKA and AURKB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer
    tumoral     --over  
    in colorectal and gastric cancers (Kaneko 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target suppression of NUF2 or NDC80 activity and/or inhibition of the NUF2-NDC80 complex formation could be a promising therapeutic target for treatment of lung cancers
    ANIMAL & CELL MODELS