SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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text
| in response to genotoxic stress in G2, the phosphatase, translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase FZR1, with the consequent degradation of PLK1, a prominent mitotic kinase |
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a fraction of CDC14B associates with centrosomes |
basic FUNCTION
| involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control |
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potential function in maintaining the fidelity of centrosome duplication cycle |
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has a central function in the G2 DNA damage checkpoint, and is potentially required for efficient DNA repair |
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serves a critical role in regulating progression through mitosis, which is distinct from CDC14A |
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CDC14B-dependent modulation of CDC25C phosphatase and CDK1 activity is tightly linked to correct chromosome segregation and bipolar spindle formation, processes that are required for proper progression through mitosis and maintenance of genomic stability |
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disrupting the cytoskeletal F-actin organization with loss of actin stress fibers and vinculin adhesions in a phosphatase-dependent manner |
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phosphatase displaying oncogenic activity mediated by the Ras-Mek signaling pathway |
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redundancy between CDC14B and CDC14A in DNA Double-Strand Break Repair repair |