basic FUNCTION
| implicated in heterochromatin association with inner nuclear membrane |
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functioning in gene silencing, transcriptional regulation and chromatin remodeling |
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is released from chromatin during the M phase of the cell cycle, upon H3 serine 10 phosphorylation |
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housekeeping genes possessing a dominant ubiquitously-acting chromatin opening element (UCOE) capability |
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involved in transient repression of inducible promoters |
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recruited to heterochromatin in association with SUV420H2, and stably maintained at its heterochromatin sites in an CBX -independent fashion |
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having a non-redundant function during spermatogenesis that cannot be compensated for by the other two CBX1 and CBX5 |
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novel role during the cellular response to oxidative stress |
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CBX3 disulfide dimerization plays a pivotal role in cell survival under oxidative conditions |
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potentially acts as a rapid redox sensor, and it may connect the intracellular redox state with transcriptional regulation under various physiological conditions |
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specific role for CBX1, CBX3, CBX5 in regulating SUV39H1 function under stress via a feedback mechanism that likely regulates heterochromatin formation |
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has an important role in carcinogenesis by regulating several mechanisms, such as heterochromatin formation, gene silencing, DNA replication and repair |