Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PHF20 contributors: mct - updated : 29-11-2013
HGNC name PHD finger protein 20
HGNC id 16098
Location 20q11.22      Physical location : 34.359.922 - 34.538.288
Synonym name
  • C2H2 zinc finger protein
  • transcription factor TZP
  • glioma-expressed antigen 2
  • hepatocellular carcinoma-associated antigen 58
  • chromosome 20 open reading frame 104
  • Synonym symbol(s) HCA58, TZP, C20orf104, NZF, GLEA2, FLJ33479, TDRD20A
    DNA
    TYPE functioning gene
    STRUCTURE 178.37 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 5899 - 1012 - 2012 22334668
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
     placenta    
    Lymphoid/Immunespleen    
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines colon and ovary cancer cell line but not expressed in the respective normal tissues
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple functional domains, including two Tudor motifs, acting as an adaptor mediating intramolecular as well as intermolecular protein-protein interactions and protein-nucleic acid associations
  • an AT-hook region
  • a C2H2 zinc finger
  • and a PHD finger domain
  • two consensus sites for protein kinase B (AKT1) phosphorylation (RxRxxS/T)
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Phf20
    Homologene
    FAMILY
    CATEGORY transcription factor , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • AKT1 induces PHF20 translocation from the nucleus to the cytoplasm
  • basic FUNCTION
  • may be a transcription factor
  • inducing a frequent immune response in glioma
  • can be considered as a potential diagnostic marker
  • inhibits cell proliferation, DNA synthesis, and cell survival
  • novel transcriptional factor and both a binding partner and substrate of AKT1
  • functions as an effector of TP53 methylation that stabilizes and activates TP53 (pMID: 22864287)
  • novel regulator of NFKB1 activation, suggesting that elevated expression of PHF20 may drive constitutive NFKB1 activation in some cancers
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • is a substrate of AKT1 and plays a role in AKT1 cell survival/growth signaling
  • directly binds to the TP53 promoter and up-regulates TP53 at the mRNA level
  • is a novel substrate for AKT1 and its phosphorylation by AKT1 plays an important role in tumorigenesis via regulating of TP53 mediated signaling
  • KDM6B-targeting of PHF20 for ubiquitination and degradation via recruitment of an E3 ligase, TRIM26
  • induces canonical NFKB1 signalling by increasing the DNA-binding activity of NFKB1 subunit RELA
  • maintains NFKB1 in an active state in the nucleus by inhibiting the interaction between PP2A and RELA
  • cell & other
    REGULATION
    Phosphorylated by AKT1, that phosphorylates PHF20 on serine 291 within a PHF20 nuclear localization signal, which leads to PHF20 translocation from the nucleus to the cytoplasm and loss of its biochemical and cellular functions
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS