Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARHGAP12 contributors: mct - updated : 28-11-2018
HGNC name Rho GTPase activating protein 12
HGNC id 16348
Location 10p11.22      Physical location : 32.095.224 - 32.217.770
Synonym symbol(s) FLJ10971, FLJ20737, FLJ21785, FLJ45709, DKFZp779N2050
DNA
TYPE functioning gene
STRUCTURE 123.48 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 splicing - - 816 heart : highly,lung,kidney,liver brain,pancreas 2008 18504429
  • two polyadenylation signals
  • 18 exons (lacking exons 8 and 9)
  • 20 splicing 4172 - 846 kidney, liver, brain, pancreas (higher than variant a), lung 2008 18504429
  • two polyadenylation signals
  • 20 exons (having exons 8 and 9)
  • 17 - 4874 - 769 - 2008 18504429
    19 - 4964 - 799 - 2008 18504429
    18 - 5015 - 816 - 2008 18504429
    19 - 5090 - 841 - 2008 18504429
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum  
     brainlimbic systemhippocampus specific Homo sapiens
     braindiencephalonamygdala  
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    cell lineage
    cell lines tumor cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SH3 domain
  • two WW domain
  • a PH domain and a rhoGAP domain
  • one zinc-dependent phorbol-ester and DAG binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila cg18856
    homolog to C.elegans r10h10.1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • stimulating the intrinsic GTP hydrolysis activity of Rho family proteins
  • ARHGAP12, ARHGAP25 and SH3BP1 are responsible for GTPase inactivation
  • is a synaptic RhoGAP that regulates excitatory synaptic structure and function during development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS