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FLASH GENE
Symbol CELF6 contributors: npt/ - updated : 28-05-2008
HGNC name CUGBP, Elav-like family member 6
HGNC id 14059
Location 15q23      Physical location : 72.577.067 - 72.612.525
Synonym name
  • bruno-like 6, RNA binding protein (Drosophila)
  • CUG-BP and ETR-3 like factor 6
  • RNA-binding protein BRUNOL-6
  • Synonym symbol(s) CELF6, CELF-6, BRUNOL6
    DNA
    TYPE functioning gene
    STRUCTURE 35.46 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3418 50.5 481 - PMID: 14761971
    - - 3081 47.5 454 - -
    - - 2854 36 344 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas    
    Nervousnerve   highly
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N-terminal RNA recognition motif (RRM) domains
  • one C-terminal RRM domain
  • a divergent segment of 160-230 AA between the second and third RRM domains
  • HOMOLOGY
    interspecies homolog to Drosophila CG10046
    homolog to C.elegans C17D12.2
    Homologene
    FAMILY
  • CELF/BRUNOL family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • regulating muscle-specific splicing enhancer-dependent alternative splicing and may also be involved in mRNA editing, and translation
  • implicated in two major post-transcriptional regulatory processes, namely the alternative splicing and the control of translation and stability of target mRNAs
  • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • target of CELF activity that is expressed in kidney
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS