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FLASH GENE
Symbol SPPL2B contributors: mct - updated : 12-09-2017
HGNC name signal peptide peptidase like 2B
HGNC id 30627
Location 19p13.3      Physical location : 2.328.628 - 2.355.099
Synonym name
  • SPP-like 2B
  • intramembrane protease 4
  • signal peptide peptidase L2B
  • presenilin-like protein 1
  • Synonym symbol(s) KIAA1532, IMP4, MGC111084, PSL1, IMP-4, PSH4
    EC.number 3.4.23.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 26.53 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3769 64.6 592 - 2011 21896273
    15 - 3832 - 511 - 2011 21896273
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuterus  highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two conserved catalytic motifs localized within the membrane-spanning regions
  • a critical GXGD motif in its C-terminal catalytic center
  • HOMOLOGY
    interspecies homolog to Drosophila CG2097
    homolog to C.elegans F25G6.2
    Homologene
    FAMILY
  • GXGD family of aspartic proteases
  • peptidase A22B family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    text in endosomal/lysosomal vesicles
    basic FUNCTION
  • promoting intramembrane proteolysis to release biologically important peptides
  • cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways
  • first member of the SPP/PSH/SPPL family that is not located within the ER but in endosomal/lysosomal vesicles
  • distinct functions of SPPL2A and SPPL2B and, high abundance of SPPL2B in brain suggests a physiological role of this protease in the central nervous system
  • SPPL2A and SPPL2B have been implicated in regulated intramembrane proteolysis (RIP) of type II transmembrane proteins
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPPL2A and SPPL2B mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the ITM2B N-terminal fragment (pMID: 17965014)
  • SPPL2A, and mainly SPPL2B are responsible for the intramembrane proteolysis of TFRC-N-terminal fragment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS