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FLASH GENE
Symbol HTR6 contributors: npt/ - updated : 10-05-2006
HGNC name 5-hydroxytryptamine (serotonin) receptor 6
HGNC id 5301
Location 1p36.13      Physical location : 19.991.779 - 20.006.054
Synonym name serotonin receptor 6
Synonym symbol(s) 5-HT6, 5-HT6R
DNA
TYPE functioning gene
STRUCTURE 14.27 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1984 - 440 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrineadrenal gland    
Nervousbrainlimbic systemhippocampus highly
Reproductivefemale systembreastmammary gland  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • C-terminal region interacts with the FYN-tyrosine kinase (Yun 2007)
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • 5-hydroxytryptamine (serotonin) receptor, activating adenylate cyclase
  • having a high affinity for tricyclic psychotropic drugs
  • biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FYN (activation of HTR6 activated the extracellular signal-regulated kinase1/2 via an FYN-dependent pathway) (Yune 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to bipolar affective disorder and schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS