Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MIOX contributors: mct/npt - updated : 15-04-2020
HGNC name myo-inositol oxygenase
HGNC id 14522
Location 22q13.33      Physical location : 50.925.212 - 50.928.750
Synonym name
  • kidney-specific protein 32
  • renal-specific oxidoreductase
  • similar to mouse aldehyde reductase 6 (renal)
  • aldehyde reductase (aldose reductase) like 6
    • Synonym symbol(s) ALDR6R, ALDRL6, KSP32, MGC90217, RSOR, C85427
    EC.number 1.13.99.1
    DNA
    TYPE functioning gene
    STRUCTURE 6.66 kb     10 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor   HRE
    text structure
  • an osmotic response element (ORE) in the promoter region, which is present approximately 2 kb upstream of the translation start sit
  • activity of the promoter is dependent on the binding of the transcription factor, tonicity element-binding protein, or osmotic response element-binding protein, to the ORE site
  • MIOX promoters, enriched with CpG sites, are hypomethylated and unmethylated under high glucose (HG) ambience and hyperglycemic states associated with increased MIOX expression
  • promoter includes oxidant-response elements, and binding sites for XBP1, a transcription factor of ER stress response
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1689 33 285 - 2017 28208054
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Aldrl6
    homolog to Drosophila mRpS7
    Homologene
    FAMILY
  • myo-inositol oxygenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • non-heme iron enzyme, catalyzing the oxidative cleavage of myo-inositol to give D-glucuronic acid, a committed step in myo-inositol catabolism
  • MIOX catalyzes the oxidative cleavage of myo-inositol (MI) to give D-glucuronic acid, a committed step in MI catabolism
  • tubular-specific enzyme, modulating redox imbalance and apoptosis in tubular cells in diabetes
  • epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy
  • MIOX expression profile modulates pathogenic ferroptosis in the renal proximal tubule
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    myo-inositol catabolism pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • high fat diet (HFD) or fatty acids modulate transcriptional, translational, and post-translational regulation of MIOX expression/activity and underscore MIOX being a novel target of the transcription factor SREBF1
    • cell & other
    REGULATION
    activated by a positive feedback mechanism where xylitol, one of the products of myo-inositol catabolism via the glucuronate-xylulose pathway, induces an overexpression of MIOX
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    drives the progression of renal tubulo-interstitial injury in diabetes
    constitutional     --over  
    in diabetic kidneys may contribute to tubulointerstitial injury and the development of diabetic nephropathy
    Susceptibility to Type 1 diabetes mellitus
    Variant & Polymorphism other
  • polymorphism (rs761745) in the promoter region of MIOX gene may be associated with the development of T1D
    • Candidate gene
    Marker
  • MIOX levels were higher in gestational diabetes mellitus (GDM) cases so, it may be have a role in myo-inositol catabolism
  • potential use of MIOX as a kidney-specific enzyme in the early diagnosis of acute kidney injury (AKI)
  • concentration of MIOX in the serum and urine may serve as a new biomarker for the early diagnosis of diabetic nephropathy (DN)
    • Therapy target
    ANIMAL & CELL MODELS
  • expression of MIOX was increased at both the mRNA and protein levels in the kidney of rats with diabetic nephropathy
  • in tubules of diabetic mice, increased MIOX expression and mitochondrial fragmentation and defective autophagy were observed